Vaginal Estradiol Cream Rx
- Local estrogen for vaginal dryness
- Reviewed by a licensed Pep’d provider
- Eases pain during sex caused by dryness
Meet Vaginal Estradiol
- A local estrogen cream for menopausal vaginal symptoms
- Treats dryness and discomfort where they happen
- Prescribed only after a full intake review
About the ingredient
- Estradiol is the main form of estrogen your ovaries make
- Low-dose vaginal estrogen acts mainly where it’s applied
- Its role differs from systemic estrogen for hot flashes
How to use the cream
- Your provider gives the dose and schedule for your cream
- Regimens often start daily, then step down over time
- Store it as your pharmacy and provider instruct
Safety information
- Some estrogen can still be absorbed into the body
- Tell your provider about breast cancer or unexplained bleeding
- Possible side effects include irritation and breast tenderness
- Desire and arousal concerns can have other causes
Local comfort, simplified
Provider reviewed
Every prescription is reviewed by a licensed clinician.
Local treatment
Applied locally for menopausal dryness and discomfort.
More comfortable sex
Shown in trials to ease pain during sex from dryness.
Pharmacy delivery
If prescribed, shipped by a licensed pharmacy to you.
Vaginal estradiol treats local symptoms. It is not a treatment for hot flashes or low desire.
Individual results vary.
How it works
- 1
Online intake
Answer questions about what you’ve been experiencing and see which treatment options you may be eligible for.
- 2
Provider evaluation
A licensed provider reviews your intake and determines if treatment is right for you.
- 3
Personalized plan
If prescribed, you’ll get a personalized treatment plan that includes medication delivered right to you.
- 4
Ongoing support
Get online access to provider messaging, regular check-ins, and treatment adjustments as needed.
Care that goes past the prescription
Along with your treatment, you get
- A licensed provider who reviews every plan
- A plan matched to your symptoms and history
- Messaging with your care team
- Regular check-ins and treatment adjustments
- Pharmacy shipping to your door, if prescribed
Treatment is provided only if a licensed provider prescribes it.
Individual results vary.
Which hormone therapy option fits your symptoms
Pep’d offers a few different hormone therapy options for menopause symptoms. Your provider decides what fits your history and goals.
Options are shown side by side for comparison only. Some are used together, and your provider decides the combination.
Estradiol Patch
Used forHot flashesHow to takeSkin patchActive ingredientEstradiol
Oral Estradiol
Used forHot flashesHow to takeBy mouthActive ingredientEstradiol
Progesterone
Used forUterine protectionHow to takeCapsule by mouthActive ingredientProgesterone
Vaginal Estradiol
Used forVaginal drynessHow to takeCream, applied vaginallyActive ingredientEstradiol
Estradiol Gel
Used forHot flashesHow to takeGel on the skinActive ingredientEstradiol
Availability and pricing are confirmed after provider review. Compounded medications are not approved or evaluated by...
Frequently asked questions
Begin intakeWhat does vaginal estradiol cream treat?
Local vaginal estrogen treats menopausal vaginal dryness and discomfort. It does not replace systemic estrogen for symptoms such as hot flashes.
How soon will dryness and irritation improve?
Many women notice improvement within a few weeks of regular use. In clinical trials, estradiol vaginal cream reduced vaginal dryness within four weeks and eased pain during sex.
How do I use vaginal estradiol cream?
Your provider gives you the dose and schedule. Regimens often start daily for a couple of weeks, then step down to a few times a week.
Is vaginal estrogen the same as a pill or patch?
No. It is a local treatment with a different role than systemic estrogen. Your provider decides whether you need one, the other, or both.
Can it help with low desire or pain with sex?
It can ease pain during sex when menopause dryness is the cause, as clinical trials have shown. Desire and arousal concerns have other possible causes, so your provider assesses them individually.
What are the risks of vaginal estrogen?
Low-dose vaginal estrogen acts mainly where it is applied, but some estrogen can still be absorbed. Your provider reviews your history, including any breast cancer or unexplained bleeding, before prescribing.
Do I also need progesterone?
Low-dose local vaginal estrogen often does not need progesterone, but your provider decides based on your dose and history.
What is included with a Pep’d prescription?
Provider review of your intake, ongoing messaging with your care team, and a personalized plan. If prescribed, medication ships from a licensed pharmacy.
Do I need an in-person visit to get started?
No. You complete your intake online and a licensed provider reviews it. Your provider will tell you if anything more is needed.
Is insurance required to get started?
No. Pep’d operates outside of insurance, and insurance is not required to get started.
Is vaginal estradiol cream available in every state?
Availability varies by state. Your intake will confirm what is available where you live.
Can my provider change my plan over time?
Yes. Your provider can adjust your plan based on how you respond and how you tolerate treatment.
How does delivery work?
If you’re prescribed, a licensed pharmacy ships your medication to your door.
Estradiol is a generic medication name, not a branded trademark. Pep’d is a trademark of Pepd LLC.
- 1. Prescription medications require a valid prescription from a licensed provider. Not available in all 50 states. Results may vary.