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Women’s HRT option

Estradiol Gel Rx

  • Systemic estrogen in a daily skin gel
  • Reviewed by a licensed Pep’d provider
  • Matched to your symptoms and history
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Important safety info
Meet Estradiol Gel
  • Systemic estrogen in a gel you apply to the skin
  • For menopause symptoms like hot flashes and night sweats
  • Prescribed only after a full intake review
About the ingredient
  • Estradiol is the main form of estrogen your ovaries make
  • The gel absorbs through the skin, skipping the liver’s first pass
  • Women with a uterus typically also take progesterone
How to apply it
  • Apply to clean, dry skin as your provider directs
  • Let it dry, then wash your hands
  • Keep the area away from others, children and pets until dry
Safety information
  • Estrogen carries risks, including blood clots and stroke
  • Estrogen alone raises uterine cancer risk, so progesterone is added if you have a uterus
  • Not for everyone. Tell your provider about clots, cancer or liver disease
  • Possible side effects include skin irritation and breast tenderness

Estrogen, on your skin

Begin intake
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    Provider reviewed

    Every prescription is reviewed by a licensed clinician.

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    Through the skin

    Estradiol absorbs through the skin, with no pill to take.

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    Adjustable dose

    Your provider can fine-tune how much gel you apply.

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    Pharmacy delivery

    If prescribed, shipped by a licensed pharmacy to you.

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Estrogen therapy carries risks. Your provider reviews your history before prescribing.

Individual results vary.

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How it works

  1. 1

    Online intake

    Answer questions about what you’ve been experiencing and see which treatment options you may be eligible for.

  2. 2

    Provider evaluation

    A licensed provider reviews your intake and determines if treatment is right for you.

  3. 3

    Personalized plan

    If prescribed, you’ll get a personalized treatment plan that includes medication delivered right to you.

  4. 4

    Ongoing support

    Get online access to provider messaging, regular check-ins, and treatment adjustments as needed.

Begin intake
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Care that goes past the prescription

Along with your treatment, you get

  • A licensed provider who reviews every plan
  • A plan matched to your symptoms and history
  • Messaging with your care team
  • Regular check-ins and treatment adjustments
  • Pharmacy shipping to your door, if prescribed
Begin intake

Treatment is provided only if a licensed provider prescribes it.

Individual results vary.

Which hormone therapy option fits your symptoms

Pep’d offers a few different hormone therapy options for menopause symptoms. Your provider decides what fits your history and goals.

Options are shown side by side for comparison only. Some are used together, and your provider decides the combination.

Availability and pricing are confirmed after provider review. Compounded medications are not approved or evaluated by...

Frequently asked questions

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How soon will hot flashes improve?

In a clinical trial of estradiol gel, hot flashes dropped significantly by week 4. Results vary, and your provider checks in on how you are responding.

How do I apply estradiol gel?

You apply a measured amount to clean, dry skin, usually once a day, on the area your provider shows you, and let it dry.

Can the gel transfer to other people?

Yes, it can. Let it dry, wash your hands, and avoid skin contact between the application area and others, including children and pets, as your provider instructs.

Do I need progesterone with estrogen?

If you have a uterus, estrogen is typically paired with progesterone to protect the uterine lining. Your provider decides what fits you.

Gel, patch or pill: how do I choose?

Each delivers systemic estrogen. A gel or patch goes through the skin, while a pill is processed by the liver first. Your provider helps you choose based on your history and preferences.

What are the risks of estrogen therapy?

Estrogen carries risks, including blood clots, stroke and breast cancer. They depend on your age, health and how long you take it, and your provider weighs them with your history first.

Does timing matter for hormone therapy?

It can. Hormone therapy is generally most favorable when started under age 60 or within 10 years of menopause. Your provider reviews your history.

What is included with a Pep’d prescription?

Provider review of your intake, ongoing messaging with your care team, and a personalized plan. If prescribed, medication ships from a licensed pharmacy.

Do I need an in-person visit to get started?

No. You complete your intake online and a licensed provider reviews it. Your provider will tell you if anything more is needed.

Is insurance required to get started?

No. Pep’d operates outside of insurance, and insurance is not required to get started.

Is estradiol gel available in every state?

Availability varies by state. Your intake will confirm what is available where you live.

Can my provider change my plan over time?

Yes. Your provider can adjust your plan based on how you respond and how you tolerate treatment.

How does delivery work?

If you’re prescribed, a licensed pharmacy ships your medication to your door.

Estradiol is a generic medication name, not a branded trademark. Pep’d is a trademark of Pepd LLC.

  1. 1. Prescription medications require a valid prescription from a licensed provider. Not available in all 50 states. Results may vary.