Oral Estradiol Rx
- Systemic estrogen in a simple pill
- Reviewed by a licensed Pep’d provider
- Matched to your symptoms and history
Meet Oral Estradiol
- Systemic estrogen therapy in a pill
- For menopause symptoms like hot flashes and night sweats
- Prescribed only after a full intake review
About the ingredient
- Estradiol is the main form of estrogen your ovaries make
- A pill is processed by the liver before it circulates
- Women with a uterus typically also take progesterone
How you take it
- Taken by mouth on the schedule your provider sets
- Your provider chooses the dose and adjusts it over time
- Store it as your pharmacy and provider instruct
Safety information
- Estrogen carries risks, including blood clots and stroke
- Estrogen alone raises uterine cancer risk, so progesterone is added if you have a uterus
- Not for everyone. Tell your provider about clots, cancer or liver disease
- Possible side effects include breast tenderness, nausea and headache
Estrogen, simplified
Provider reviewed
Every prescription is reviewed by a licensed clinician.
Simple routine
Taken by mouth, so there’s nothing to apply or change.
Decades of research
Estradiol hormone therapy has been studied for decades.
Pharmacy delivery
If prescribed, shipped by a licensed pharmacy to you.
Estrogen therapy carries risks. Your provider reviews your history before prescribing.
Individual results vary.
How it works
- 1
Online intake
Answer questions about what you’ve been experiencing and see which treatment options you may be eligible for.
- 2
Provider evaluation
A licensed provider reviews your intake and determines if treatment is right for you.
- 3
Personalized plan
If prescribed, you’ll get a personalized treatment plan that includes medication delivered right to you.
- 4
Ongoing support
Get online access to provider messaging, regular check-ins, and treatment adjustments as needed.
Care that goes past the prescription
Along with your treatment, you get
- A licensed provider who reviews every plan
- A plan matched to your symptoms and history
- Messaging with your care team
- Regular check-ins and treatment adjustments
- Pharmacy shipping to your door, if prescribed
Treatment is provided only if a licensed provider prescribes it.
Individual results vary.
Which hormone therapy option fits your symptoms
Pep’d offers a few different hormone therapy options for menopause symptoms. Your provider decides what fits your history and goals.
Options are shown side by side for comparison only. Some are used together, and your provider decides the combination.
Estradiol Patch
Used forHot flashesHow to takeSkin patchActive ingredientEstradiol
Oral Estradiol
Used forHot flashesHow to takeBy mouthActive ingredientEstradiol
Progesterone
Used forUterine protectionHow to takeCapsule by mouthActive ingredientProgesterone
Vaginal Estradiol
Used forVaginal drynessHow to takeCream, applied vaginallyActive ingredientEstradiol
Estradiol Gel
Used forHot flashesHow to takeGel on the skinActive ingredientEstradiol
Availability and pricing are confirmed after provider review. Compounded medications are not approved or evaluated by...
Frequently asked questions
Begin intakeHow long until hot flashes improve?
In clinical trials of oral estradiol and estradiol patches, hot flashes dropped significantly as early as week 4. Results vary by person.
How often do I take oral estradiol?
Oral estradiol is usually taken once a day. Your provider sets the dose and tells you when to take it.
Do I need progesterone with estrogen?
If you have a uterus, estrogen is typically paired with progesterone to protect the uterine lining. Your provider decides what fits you.
Pill, patch or gel: how do I choose?
Each delivers systemic estrogen. A pill is processed by the liver first, while a patch or gel goes through the skin. Your provider helps you choose based on your history and preferences.
Does estradiol help protect my bones?
Systemic estrogen therapy helps prevent bone loss after menopause. It is not the right choice for everyone, so your provider weighs it against your other risks.
What are the risks of estrogen therapy?
Estrogen carries risks, including blood clots, stroke and breast cancer. They depend on your age, health and how long you take it, and your provider weighs them with your history first.
Does timing matter for hormone therapy?
It can. Hormone therapy is generally most favorable when started under age 60 or within 10 years of menopause. Your provider reviews your history.
What is included with a Pep’d prescription?
Provider review of your intake, ongoing messaging with your care team, and a personalized plan. If prescribed, medication ships from a licensed pharmacy.
Do I need an in-person visit to get started?
No. You complete your intake online and a licensed provider reviews it. Your provider will tell you if anything more is needed.
Is insurance required to get started?
No. Pep’d operates outside of insurance, and insurance is not required to get started.
Is oral estradiol available in every state?
Availability varies by state. Your intake will confirm what is available where you live.
Can my provider change my plan over time?
Yes. Your provider can adjust your plan based on how you respond and how you tolerate treatment.
How does delivery work?
If you’re prescribed, a licensed pharmacy ships your medication to your door.
Estradiol is a generic medication name, not a branded trademark. Pep’d is a trademark of Pepd LLC.
- 1. Prescription medications require a valid prescription from a licensed provider. Not available in all 50 states. Results may vary.