Estradiol Patch Rx
- Steady estradiol delivered through the skin
- Reviewed by a licensed Pep’d provider
- Matched to your symptoms and history
Meet the Estradiol Patch
- A skin patch that delivers estradiol steadily
- For menopause symptoms like hot flashes and night sweats
- Prescribed only after a full intake review
About the ingredient
- Estradiol is the main form of estrogen your ovaries make
- The patch delivers it through the skin, skipping the liver’s first pass
- Women with a uterus typically also take progesterone
How to use the patch
- Apply to clean, dry skin as your provider directs
- Change it once or twice a week, depending on the patch
- Rotate where you place it each time
Safety information
- Estrogen carries risks, including blood clots and stroke
- Estrogen alone raises uterine cancer risk, so progesterone is added if you have a uterus
- Not for everyone. Tell your provider about clots, cancer or liver disease
- Possible side effects include skin irritation and breast tenderness
Estrogen, simplified
Provider reviewed
Every prescription is reviewed by a licensed clinician.
Steady delivery
A patch delivers estradiol continuously through the skin.
Skips the liver
Skin delivery bypasses first pass through the liver.
Pharmacy delivery
If prescribed, shipped by a licensed pharmacy to you.
Estrogen therapy carries risks. Your provider reviews your history before prescribing.
Individual results vary.
How it works
- 1
Online intake
Answer questions about what you’ve been experiencing and see which treatment options you may be eligible for.
- 2
Provider evaluation
A licensed provider reviews your intake and determines if treatment is right for you.
- 3
Personalized plan
If prescribed, you’ll get a personalized treatment plan that includes medication delivered right to you.
- 4
Ongoing support
Get online access to provider messaging, regular check-ins, and treatment adjustments as needed.
Care that goes past the prescription
Along with your treatment, you get
- A licensed provider who reviews every plan
- A plan matched to your symptoms and history
- Messaging with your care team
- Regular check-ins and treatment adjustments
- Pharmacy shipping to your door, if prescribed
Treatment is provided only if a licensed provider prescribes it.
Individual results vary.
Which hormone therapy option fits your symptoms
Pep’d offers a few different hormone therapy options for menopause symptoms. Your provider decides what fits your history and goals.
Options are shown side by side for comparison only. Some are used together, and your provider decides the combination.
Estradiol Patch
Used forHot flashesHow to takeSkin patchActive ingredientEstradiol
Oral Estradiol
Used forHot flashesHow to takeBy mouthActive ingredientEstradiol
Progesterone
Used forUterine protectionHow to takeCapsule by mouthActive ingredientProgesterone
Vaginal Estradiol
Used forVaginal drynessHow to takeCream, applied vaginallyActive ingredientEstradiol
Estradiol Gel
Used forHot flashesHow to takeGel on the skinActive ingredientEstradiol
Availability and pricing are confirmed after provider review. Compounded medications are not approved or evaluated by...
Frequently asked questions
Begin intakeHow long until hot flashes improve?
In clinical trials of oral estradiol and estradiol patches, hot flashes dropped significantly as early as week 4. Results vary by person.
How often do I change the patch?
Depending on the patch, you change it once or twice a week. Your provider tells you which type you have.
Do I need progesterone with estrogen?
If you have a uterus, estrogen is typically paired with progesterone to protect the uterine lining. Your provider decides what fits you.
Patch or pill: what is the difference?
A patch delivers estradiol through the skin, skipping first pass through the liver. A pill is processed by the liver first. Observational studies suggest transdermal estrogen may carry a lower clot risk, and your provider weighs your own history.
Can I shower or swim with the patch on?
Estradiol patches are designed to stay on in the shower, but follow the instructions that come with yours and ask your provider what to do if one comes off.
What are the risks of estrogen therapy?
Estrogen carries risks, including blood clots, stroke and breast cancer. They depend on your age, health and how long you take it, and your provider weighs them with your history first.
Does timing matter for hormone therapy?
It can. Hormone therapy is generally most favorable when started under age 60 or within 10 years of menopause. Your provider reviews your history.
What is included with a Pep’d prescription?
Provider review of your intake, ongoing messaging with your care team, and a personalized plan. If prescribed, medication ships from a licensed pharmacy.
Do I need an in-person visit to get started?
No. You complete your intake online and a licensed provider reviews it. Your provider will tell you if anything more is needed.
Is insurance required to get started?
No. Pep’d operates outside of insurance, and insurance is not required to get started.
Is estradiol patch available in every state?
Availability varies by state. Your intake will confirm what is available where you live.
Can my provider change my plan over time?
Yes. Your provider can adjust your plan based on how you respond and how you tolerate treatment.
How does delivery work?
If you’re prescribed, a licensed pharmacy ships your medication to your door.
Estradiol is a generic medication name, not a branded trademark. Pep’d is a trademark of Pepd LLC.
- 1. Prescription medications require a valid prescription from a licensed provider. Not available in all 50 states. Results may vary.